This is some general info about where the events are located. This is from experience from the last few years, but things do move.
The exhibit hall is located in halls F to K of the ICC, which are at the top (south) of the ICC map. Halls A to E contain a large number of events, and the HQs for many of the large gaming companies. The HQs are where they run their ticketed events, as opposed to free demos & games in the exhibit hall. Pathfinder & Starfinder events run by Paizo are in the the Sagamore ballroom on the 2nd floor of the ICC. Many of the smaller rooms on the 1st & 2nd floor of the ICC contain RPG events, and there are some smaller companies and organizations that have a room. Some of these rooms have lectures, seminars, and I think the auction is there as well.
LOS (Lucas Oil Stadium) is about a 5-10 minute walk south from the ICC (all enclosed). True Dungeon is held there, underneath the stands, and there are a number of varied events and some HQs on the playing field.
Events are also held in several of the surrounding hotels. The Hyatt, Westin, Marriot, JW Marriot, Embassy Suites, Omni, Crowne Plaza, and possibly others all have things going on. Most of these hotels are north & east of the ICC, and are connected by walkways.
I think most of the escape room events are at a local escape room business, a few blocks from the ICC.
Right now, most of the events don't have locations, so it's hard to tell where stuff is. The best bet is not to schedule back-to-back events unless they are very close, such as two events run by CMON, which would both be at their HQ in Hall A. Note that even though you might be in two CMON games (like Zombicide and Narcos), they may not be run by CMON, but by 3rd parties, and could be anywhere. Check the Gaming Group/Company on the event.
If you're doing TD, give yourself at least an hour before (longer if you want to buy/trade tokens), and 30 minutes after the event. Also, since it's 2 hours on your feet, you might want to plan to relax for a while after it.
Even if events are next to each other, you need to consider bio breaks, snacking, and getting drinks, and some events can run long.
To the OP, as this is your first Gen Con, don't overbook yourself. Unless you have two "must-have" events that you can't get any alternate times for, give yourself at least 30 minutes or more between events.